2017 Section 7 Green Book

V.

Lymphatic System: Sentinel Node Biopsy Agrawal A, Civantos FJ, Brumund KT, et al. [ (99m) Tc]Tilmanocept accurately detects sentinel lymph nodes and predicts node pathology status in patients with oral squamous cell carcinoma of the head and neck: results of a phase III multi-institutional trial. Ann Surg Oncol . 2015; 22(11):3708-3715. EBM level 1.............................................................105-112 Summary : Sentinel lymph node biopsy using [99mTc]tilmanocept accurately predicted nodal status in oral cavity head and neck squamous cell carcinoma with a low false-negative rate, high negative predicative value, and high accuracy. This study demonstrates this may be a method used in conjunction with or in lieu of elective neck dissection, but future studies are warranted. Durham AB, Lowe L, Malloy KM, et al. Sentinel lymph node biopsy for cutaneous squamous cell carcinoma on the head and neck. JAMA Otolaryngol Head Neck Surg . 2016; 142(12):1171-1176. EBM level 4..................................................................................113-118 Summary : This study conducted a retrospective review of sentinel lymph node biopsy in cutaneous squamous cell carcinoma. Analysis by serial step sectioning and immunohistochemistry increased the sentinel lymph node biopsy positivity rate to 15.1%.

Mehta V, Nathan CA. What is the role of sentinel lymph node biopsy in early-stage oral cavity carcinoma? Laryngoscope . 2016; 126(1):9-10. EBM level 4...........................119-120

Summary : This paper presents a review of the role of sentinel lymph node biopsy in early-stage oral cavity carcinoma.

Schilling C, Stoeckli SJ, Haerle SK, et al. Sentinel European Node Trial (SENT): 3-year results of sentinel node biopsy in oral cancer. Eur J Cancer . 2015; 51(18):2777-2784. EBM level 2..............................................................................................................................121-128

Summary : This is a prospective study of sentinel lymph node biopsy in oral cancer. The results show excellent sensitivity, positive predicative value, and survival when employed for oral cancer.

VI.

Quality of Life Reeve BB, Cai J, Zhang H, et al. Factors that impact health-related quality of life over time for individuals with head and neck cancer. Laryngoscope . 2016; 126(12):2718-2725. EBM level 4..............................................................................................................................129-136 Summary : This study is a population-based longitudinal cohort study which attempts to identify sociodemographic, behavioral, and clinical factors associated with health-related quality of life (HRQOL) for head and neck cancer patients over time by administering a questionnaire at baseline, 22 months, and 42 months. Its strength is the largenumber of patients (587). Rettig EM, D'Souza G, Thompson CB, et al. Health-related quality of life before and after head and neck squamous cell carcinoma: analysis of the Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey linkage. Cancer . 2016; 122(12):1861-1870. EBM level 4....................................................................................................................137-146 Summary : Quality of life (QOL) for older individuals with head and neck squamous cell carcinoma was examined using the SEER database. The records of 1653 patients were examined. The authors noted that QOL declines both before and after head and neck squamous cell carcinoma, and any observed posttreatment recovery is likely an artifact of shorter survival among individuals with the lowest QOL.