2017 Section 7 Green Book

Sethugavalar B, Teo MT, Buchan C, et al. Impact of prophylactic gastrostomy or reactive NG tube upon patient-reported long term swallow function following chemoradiotherapy for oropharyngeal carcinoma: a matched pair analysis. Oral Oncol . 2016; 59:80-85. EBM level 3..............................................................................................................................147-152 Summary : This study is a retrospective matched-pair analysis looking at patient-reported long-term swallow function following chemoradiotherapy for locally advanced oropharyngeal cancer in relation to the use of a prophylactic gastrostomy or reactive nasogastric tube. The authors found that patients with prophylactic use of a gastrostomy tube had worse long-term swallow function. Treatment Modalities Update: Robotic Surgery Choby GW, Kim J, Ling DC, et al. Transoral robotic surgery alone for oropharyngeal cancer: quality-of-life outcomes. JAMA Otolaryngol Head Neck Surg . 2015; 141(6):499-504. EBM level 4..............................................................................................................................153-158 Summary : This is a retrospective cohort of patients treated with primary surgery (transoral robotic surgery) for oropharyngeal squamous cell carcinoma followed by adjuvant therapy if indicated. The results demonstrate high quality-of-life scores and low gastrostomy tube placement rates. Kumar B, Cipolla MJ, Old MO, et al. Surgical management of oropharyngeal squamous cell carcinoma: survival and functional outcomes. Head Neck . 2016; 38 Suppl 1:E1794-1802. EBM level 3....................................................................................................................159-167 Summary : This is a large case series of surgically managed oropharyngeal squamous cell carcinoma. The authors demonstrated the superiority of the transoral approach over the open approach, and also delineated novel patient stratifications based on patient and tumor characteristics. Surgery appeared to negate the negative impact smoking and neck disease typically imparts for oropharyngeal squamous cell carcinoma patients. VIII . Treatment Modalities Update: Immunotherapy Andtbacka RH, Agarwala SS, Ollila DW, et al. Cutaneous head and neck melanoma in OPTiM, a randomized phase 3 trial of talimogene laherparepvec versus granulocyte- macrophage colony-stimulating factor for the treatment of unresected stage IIIB/IIIC/IV melanoma. Head Neck . 2016; 38(12):1752-1758. EBM level 2..................................168-174 Summary : This study looks at intralesional injection of unresectable stage IIIB/IIIC/IV melanoma with the oncolytic virus talimogene laherparepvec. Durable response rate was higher for talimogene laherparepvec–treated patients than for granulocyte-macrophage colony-stimulating factor treated patients (36.1% vs 3.8%; p = 5.001). Yimaer W, Abudouyimu A, Tian Y, et al. Efficacy and safety of vascular endothelial growth factor receptor tyrosine kinase inhibitors in the treatment of advanced thyroid cancer: a meta- analysis of randomized controlled trials. Onco Targets Ther . 2016; 9:1167-1173. EBM level 1..............................................................................................................................175-181 VII.

Summary : This paper is a meta-analysis of randomized controlled trials looking at vascular endothelial growth factor receptor tyrosine kinase inhibitors.