2017 Section 7 Green Book

IX.

Inflammatory: GERD Role in Cancer Development and Prevention Busch EL, Zevallos JP, Olshan AF. Gastroesophageal reflux disease and odds of head and neck squamous cell carcinoma in North Carolina. Laryngoscope . 2016; 126(5):1091-1096. EBM level 3....................................................................................................................182-187 Summary : This study is a large population case-control study of head and neck cancer in North Carolina. The authors found no increased odds of head and neck cancer with self-reported heartburn symptoms or self-reported medical diagnosis of gastroesophageal reflux disease. These results held true for subgroup analysis for specific tumor sites as well. Papagerakis S, Bellile E, Peterson LA, et al. Proton pump inhibitors and histamine 2 blockers are associated with improved overall survival in patients with head and neck squamous carcinoma. Cancer Prev Res (Phila) . 2014; 7(12):1258-1269. EBM level 3..............188-199 Summary : This is a large prospective cohort of head and neck squamous cell carcinoma patients in which histamine receptor-2 antagonists (H2RAs) and proton pump inhibitor (PPI) use and treatment outcomes were examined. The findings demonstrated that both medications were significant prognostic factors for overall survival ,but that only H2RAs were associated with recurrence-free survival in HPV16-positive oropharyngeal squamous cell carcinoma patients.