2017_SBRT_Course Book

Multi metastases (6-17median ; range 5-35)

Authors PTS

Range of mets./Total volume/ pts

Inclusion criteria Media n follow up

Local recurrence

DBF/Time to DBF

OS (median)

Yamamoto N=208

5-10 (6) Mean= 3.54 cc

>3 mets Cum.Tu vol ≤ 15cc KPS ≥70% 100% no prior WBRT

12 mo 1 y =6.5% 2 y =9.8%

1 y = 63% 2 y =72% Median 8.04 mo

10.8 mo

Mohammadi N=178

5-20 (6) median 3.2cc

KPS ≥70% (46% no prior WBRT) 3 brain mets 83% prior or adjuvant brain mets

6.2 mo Crude : 3% Crude

6.7 mo

40%/=2.1 mo

Bhatnagar N=205

4-18 (5) NR=CC

Mean 8.0 mo

1 y=29% 1 y =43%

8.0 mo

Median 9 mo

• Limited data • In patients up to 10 mets. , the expected distant brain failure rate is not greater than would be expected for patients with limited brain mets.