2017_SBRT_Course Book

IMRT / VMAT with SIB in Patients with Brain Oligometastases

Author

Endpoint

PTV wb/dose PTV m/dose

Cases (lesions)

Main findings

Bauman 2007

WBRT +SIB (HT) vs WBRT + conventional SRT

30 (60)

14 (1-3)

SIB HT is a feasible alternative for SRT on small volume

Edwards 2010

WBRT + SIB(HT)

30 (40)

11 (1-4)

WBRT + SIB (HT) is feasible without adverse effects SIB-VMAT plans achieve adequate WBRT coverage with conformal hippocampal avoidance and RS quality dose distributions 60 Gy in 10 fract. To 1-3 brain metastases synchronously with 30 Gy WBRT 47.5 Gy in 5 fract.. Volumetric RS was effective for long term control

Hsu 2010

WBRT + SIB (VMAT) vs SRT

32.23 (63-70.8)

10 (1-3)

Rodrigues 2011

WBRT+ SIB (HT)

30 (35-60)

48 (1-3)

Nichol 2016

WBRT +VRS

20 (47.5 to metastases, 38 to 2 mm PTV)

60 (223)

Ferro 2017

WBRT + SIB (IMRT)

30 (35-50)

30 (1-5)

50 Gy in 10 fract. To 1-5 brain metastases synchron. With 30 Gy WBRT is feasible with IMRT