2018 - March 12 SPSFAM Meeting Book

Action Items from 2017 Annual Meeting Held in Atlanta, Georgia • A draft Fitness for Purpose Statement was developed and  accepted by the Stakeholder Panel for the method which  was to be based on LC‐tandem MS. • The method must be capable of checking the compliance  with respect to worldwide regulatory limits. • Fitness For Purpose Statement:  The method should be  applicable to the analysis of veterinary drugs in: – Raw food materials  such as raw milk, meat, fish,  seafood and eggs; – Semi finished food products such as skimmed milk  powder, whey protein concentrate/hydrolysate, lactose,  meat powder and related materials; and  – Finished products including infant formula, milk and  meat‐based infant cereals, and baby foods

Working Group Activities since the 2017 Annual Meeting • It was clarified that the LC‐MS/MS method to be  developed should be capable of detecting the  presence and/or absence of a target analyte in the  applicable matrix with the capacity to provide  identification of the analyte of interest.  • In that respect, it will have to meet the guidelines  for qualitative chemistry methods published as – Appendix N (2013; ISPAM Guidelines for Validation of  Qualitative Binary Chemistry Methods) and 

– Appendix H (2012; Probability of Detection as a  Statistical Model for the Validation of Qualitative  Chemistry Methods)