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Small Bowel: Dose / Volume distribution in 31

patientsxx

treated to mean target doses of 72.3 Gy(RBE) (range:

64-76)

Volume

mean (cc)

range (cc)

V 5 (24 pts.)

86.5

2.0 - 238

V20 (24 pts.)

45.1

0.2 - 151

V30 (22 pts.)

35.5

0.1 - 120

V40 (20 pts.)

27.5

0.2 - 89.0

V50 (19 pts.)

17.7

0.2 - 59.0

V60 (17 pts.)

7.6

0.4 - 29.0

V70 (12 pts.)

2.4

0.1 - 11.0

Volume

mean (cc)

range (cc)

V75 (10 pts.)

1.9

<0.1 - 3.1

V80 (4 pts.)

0.2

<0.1 - 0.5

XX = volume definition and analysis based on initial planning CT

Results at PSI

(Schneider et al., 2010, ASTRO presentation)

Using the sharp dose fall-off, proton therapy can deliver

high doses to posterior bowel walls, yet only moderate

doses to anterior bowel walls

Small bowel can tolerate well doses > 60 Gy(RBE), as long as

not circumferenPal