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Establishing Evidence-Based Indica3ons for Proton Therapy: An Overview of Current Clinical
Trials
Mark V. Mishra, Univ. Maryland, IJROBP, 2017 (97)
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clinicaltrials.gov and the World Health Organiza3on Interna3onal Clinical Trials PlaSorm
Registry.
➢
Total of 122 ac3ve PBT clinical trials iden3fied
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Target enrollment of >42,000 pa3ents worldwide.
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96 trials (79%), classified as interven3onal studies.
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Observa3onal studies accounted for 21% of trials but 71% (n=29,852) of planned pa3ent
enrollment.
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Most common: Gastrointes3nal tract tumors (21%, n=26), tumors of the central nervous
system (15%, n=18), and prostate cancer (12%, n=15).
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5 ac3ve studies (lung, esophagus, head and neck, prostate, breast) will randomize pa3ents
between protons and photons, and 3 will randomize pa3ents between protons and carbon ion
therapy.