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Dealing with uncertainties

Worse case (1 fraction)

20 fractions

Single fraction dose uncertainties

CI85% = 1.76mm

Albertini et al (2010)

Full treatment dose uncertainties (37

fractions)

Lowe et al (2016)

IMPT plan to skull base chordoma

Fractionation

Robust optimisation – What is a good robustness metric?