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studies with larger numbers will help define effect of treat-
ment and clarify the appropriate frequency for follow-up
evaluation. To reduce potential cofounders, further studies
may benefit from tightly controlling for untreated voice
abuse and LPR. Additionally, analyzing differences in out-
comes between patients who continue to smoke and those
who have quit may define the impact of continued tobacco
use on Reinke’s edema and healing following photoangioly-
tic laser intervention. Finally, attention toward procedural
details to optimize comfort and minimize anxiety may
improve procedure tolerability in a broader population.
Author Contributions
Ian J. Koszewski
, study design; data interpretation; data analysis;
drafting manuscript; final approval of manuscript; accountable for
all aspects of work;
Matthew R. Hoffman
, study design; data
interpretation; data analysis; drafting manuscript; final approval of
manuscript; accountable for all aspects of work;
W. Greg Young
,
study design; data acquisition; data analysis; critical revision of
manuscript; final approval of manuscript; accountable for all
aspects of work;
Ying-Ta Lai
, study design; data acquisition; data
analysis; critical revision of manuscript; final approval of manu-
script; accountable for all aspects of work;
Seth H. Dailey
, study
design; performed surgical procedures; data interpretation; critical
revision of manuscript; final approval of manuscript; accountable
for all aspects of work.
Disclosures
Competing interests:
None.
Sponsorships:
None.
Funding source:
None.
References
1. Dursun G, Ozgursoy OB, Kemal O, Coruh I. One-year follow-
up results of combined use of CO
2
laser and cold instrumenta-
tion for Reinke’s edema surgery in professional voice users.
Eur Arch Otorhinolaryngol
. 2007;264:1027-1032.
2. Marcotullio D, Magliulo G, Pezone T. Reinke’s edema and
risk factors: clinical and histopathologic aspects.
Am J
Otolaryngol
. 2002;23:81-84.
3. Chung JH, Tae K, Lee YS, et al. The significance of laryngo-
pharyngeal reflux in benign vocal mucosal lesions.
Otolaryngol
Head Neck Surg
. 2009;141:369-373.
4. Cipriani NA, Martin DE, Corey JP, et al. The clinicopatholo-
gic spectrum of benign mass lesions of the vocal fold due to
vocal abuse.
Int J Surg Path
. 2011;19:583-587.
5. Kamargiannis N, Gouveris H, Katsinelos P, et al. Chronic
pharyngitis is associated with severe acidic laryngopharyngeal
reflux in patients with Reinke’s edema.
Ann Otol Rhinol
Laryngol
. 2011;120:722-726.
6. Hojslet PE, Moesgaard-Nielsen V, Karlsmore M. Smoking
cessation in chronic Reinke’s oedema.
J Laryngol Otol
. 1990;
104:626-628.
7. Hirano M, Shin T, Morio M, et al. An improvement in surgical
treatment for polypoid vocal cord: sucking technique.
Otologia
(Fukuoka)
. 1976;22:583-589.
8. Tan NCW, Pittore B, Puxeddu R. The ‘‘M’’ shaped microflap
for treatment of complex Reinke’s space oedema of the vocal
cords.
Acta Otorhinolaryngologica Italica
. 2010;30:259-263.
9. Sant’Anna GD, Mauri M.Use of the microdebrider for
Reinke’s edema surgery.
Laryngoscope
. 2000;110:2114-2116.
10. Yates A, Dedo HH.Carbon dioxide laser enucleation of poly-
poid vocal cords.
Laryngoscope
. 1984;94:731-736.
11. Remacle M, Lawson G, Watelet JB. Carbon dioxide laser
microsurgery of benign vocal fold lesions: indications, tech-
niques, and results in 251 patients.
Ann Otol Rhinol Laryngol
.
1999;108:156-164.
12. Lumpkin SM, Bishop SG, Bennett S. Comparison of surgical
techniques in the treatment of laryngeal polypoid corditis.
Ann
Otol Rhinol Laryngol
. 1987;96:254-257.
13. Pitmann MJ, Lebowitz-Cooper A, Iacob C, Tan M. Effect of
the 532nm pulsed KTP laser in the treatment of Reinke’s
edema.
Laryngoscope
. 2012;122:2786-2792.
14. Sheu M, Sridharan S, Kuhn M, et al. Multi-institutional experi-
ence with the in-office potassium titanyl phosphate laser for
laryngeal lesions.
J Voice
. 2012;26:806-810.
15. Koufman JA, Rees CJ, Frazier WD, et al. Office-based laryn-
geal laser surgery: a review of 443 cases using three wave-
lengths.
Otolaryngol Head Neck Surg
. 2007;137:146-151.
16. Rees CJ, Halum S, Wijewickrama RC, Koufman JA, Postma
GN. Patient tolerance of in-office pulsed dye laser treatments
to the upper aerodigestive tract.
Otolaryngol Head Neck Surg
.
2006;134:1023-1027.
17. Zeitels SM, Burns JA. Office-based laryngeal laser surgery
with the 532-nm pulsed-potassium-titanyl-phosphate laser.
Curr Opin Otolaryngol Head Neck Surg
. 2007;15:394-400.
18. Rees CJ, Postma GN, Koufman JA. Cost savings of unsedated
office-based laser surgery for laryngeal papillomas.
Ann Otol
Rhinol Laryngol
. 2007;116:45-48.
19. Klussmann JP, Knoedgen R, Wittekindt C, Damm M, Eckel
HE. Complications of suspension laryngoscopy.
Ann Otol
Rhinol Laryngol
. 2002;111:972-976.
20. Wuyts FL, de Bodt MS, Molenberghs G, et al. The dysphonia
severity index: an objective measure of vocal quality based on
a multiparameter approach.
J Speech Lang Hear Res
. 2000;43:
796-809.
21. Jacobson BH, Johnson A, Grywalski C, et al. The Voice
Handicap Index (VHI): development and validation.
Amer J
Speech Lang Pathol
. 1997;6:66-70.
22. Yan Y, Olszewski AE, Hoffman MR, et al. Use of lasers in
laryngeal surgery.
J Voice
. 2010;24:102-109.
23. Martins RH, Dominques MA, Fabro AT, Dias NH, Santana
MF. Reinkes’ edema: immunoexpression study of fibronectin,
laminin and collagen IV in 60 cases by immunohistochemical
techniques.
Braz J Otorhinolaryngol
. 2009;75:821-825.
24. Mallur PS, Tajudeen BA, Aaronson N, Branski RC, Amin
MR. Quantification of benign lesion regression as a function
of 532-nm pulsed potassium titanyl phosphate laser parameter
selection.
Laryngoscope
. 2011;121:590-595.
25. Branski RC, Barbieri SS, Weksler BB, et al. Effects of trans-
forming growth factor-beta1 on human vocal fold fibroblasts.
Ann Otol Rhinol Laryngol
. 2009;118:218-226.
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