1208 / 1241
Before RT
at 4 months
Metabolically active voxel, no radionecrosis
6 months later
Laprie et al, IJROBP 2008
Statistically significant pronostic value compared with conventional imaging
80% of voxels with new contrast enhancing lesions were cho/NAA>2 before RT versus
20% of voxels with new contrast enhancing lesions were cho/NAA<2
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
T1CE with CNR2 before RT T1CE with normal CNR
before RT
other
T1CE with CNR2 at relapse
MR spectroscopy value for RT ?
Results from imaging performed in a prospective trial
MR spectroscopic imaging for dose-painting
Metabolic maps of CHO/NAA >2