1232 / 1241
Predictive value of MR spectroscopy lactate/Naa ratio ?
•
Surrogate of tumor hypoxia
•
4 millions voxels analysed, data from previous trial Zarnestra
•
Definition of a significant threshold of Lactates/NAA > 0.4 using
ROC curves
•
Statistically significant predictivity for relapse
–
71% of voxels with LNR0,4 are contrast enhancing at
relapse vs 10% with LNR<0,4.
•
tendency for EFS
Deviers et al, IJROBP 2014
MR spectroscopic imaging for dose-painting
42