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25 primary NSCLC ,

4 conturing methods:

1 visual, 3 thresholding

correlation of differences with

- SUV

max

- size of lesion

- FDG-inhomogeneity

GTV

40

54 ml

GTVbg

95 ml

GTV2.5

165 ml

GTVvis

158 ml

0

60

120

180

mean volume (ml)

p=0.0004

p=0.0002

GTV

40

GTV

bg

Nestle JNM 2005

But: how?