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(> Aortic arch)

40 %

50%

60 %

70 %

Overlap fraction

70 %

80 %

90 %

Pre-radiotherapy scan:

Post-radiotherapy scan:

Residue

34 %

GTV

overlapping area

smallest volume

overlap fraction =

50%

70 %

Aerts et al. Int J Radiat Oncol

Biol Phys 2008;71:1402-1407

Question 1: Do the high-uptake areas within the tumor remain at

the same location during radiotherapy?