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Standard of care: general agreement

Exclusive Radiochemotherapy

MMC/5FU (or capecitabine)

(CDDP/5FU)

No benefit for neoadjuvant chemotherapy

No benefit for maintenance

IMRT

Can reduce acute toxicity

High gradient dose between tumor

and normal tissue

Needs accurate delineation and control

No Gap

Good outcomes:

5-year survival=70 %