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25 primary NSCLC tumors,

4 contouring methods:

1 visual, 3 thresholding

correlation of differences with

- SUV

max

- size of lesion

- FDG-Inhomogeneity

GTV

40

54 ml

GTV

bg

95 ml

GTV

2.5

165 ml

GTV

vis

158 ml

0

60

120

180

mean volume (ml)

p=0.0004

p=0.0002

GTV

40

GTV

bg

Nestle JNM 2005

However: the contouring method matters!