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DWI and treatment response of GBM
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Most studies evaluate ADC values within regions of abnormal T2/FLAIR or
contrast enhancmeent
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Increase in normalized ADC post RT : consistent with treatment response
Li et al, neurooncol 2011
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Tumor progression exhibits lower ADC values post RT compared with stable
disease
Lutz et al JMRI 2013
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ADC changes may have prognostic impliations in patients treated with
bevacizumab ( significant alterations in CE)
Pope AJN2011
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Study in 27 patients of isolated ADC hypointensity without corresponding CE
-> in 85% of the cases CE developed at the site of ADC hypointensity
Gupta et al AJN 2011