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DCE : dynamic contrast enhancement
or permeability MRI
•
based on the acquisition of serial T1-weighted images before, during, and after
administration of gadolinium-based contrast agent.
•
DCE MR perfusion imaging depicts the wash-in, plateau, and washout contrast kinetics of
the tissue
insight into the nature of the bulk tissue properties at
the microvascular level.
•
Most often, DCE MR perfusion imaging is based on
a two-compartmental
(plasma space
and extravascular-extracellular space) pharmacokinetic model.
•
The general steps are (in order):
–
perform baseline T1 mapping,
–
acquire DCE MR perfusion images,
–
convert signal intensity data to gadolinium concentration,
–
determine the vascular input function, and perform pharmacokinetic modeling.
•
The most frequently used metric in DCE MR perfusion is
k trans
. It can have different
interpretations depending on blood flow and permeability.