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Castellucci et al, Eur J Nucl Med Mol Imaging, 2011
Giovacchini et al, J Urol, 2013
Castellucci and Picchio, Eur J Nucl Med Mol Imaging, 2013
Evangelista L. Clin Nuc Med., 2013
The best predictors of positive imaging at low PSA level
(<1/1.5 ng/ml) are PSA kinetics (PSA doubling time)
Imaging approach
Patient
population
Detection rates
Castellucci
et al
11C-choline
PET/CT
PSA<1.5 ng/ml
Overall: 28%
PSA DT <7 months: 58%
Giovacchini
et al
11C-choline
PET/CT
PSA<1.5 ng/ml
(n=75)
Overall 21%
PSADT<6 months: 50%
Choline PET – PSA Dependency