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P
rostate-
S
pecific
M
embrane
A
ntigen
(
PSMA
)
•
PSMA,
also known as
Glutamate
carboxypeptidase II
,
is a type II
transmembrane glycoprotein (Upon ligand
binding PSMA is internalized with bound
molecules)
•
PSMA is expressed in a number of tissues
including prostate, kidney, and both the
central and peripheral nervous systems.
•
PSMA is an established cancer marker. In
particular, it is upregulated in prostate
cancer and has proven to be an effective
diagnostic and prognostic indicator of cancer.
•
Ideal
for
developing
targeted
radiopharmaceuticals (fast blood clearance
and low background activity)