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Biological concept

• Start of treatment

• Damage to tumor cells

Days

• Loss of cellular functions

PET

• Cell death (apoptosis)

• Leakage of signal molecules

• Activation of immune system

• Increase of mass and perfusion

Weeks

• Tissue fragments and fagocytosis

dwiMR

• Formation of scar tissue

• Reduction in perfusion

ceMR

• Shrinkage of tumor mass

Months

CT

• End result

12