McKenna's Pharmacology for Nursing, 2e - page 149

136
P A R T 2
 Chemotherapeutic agents
TABLE 10.3
DRUGS IN FOCUS Agents for HIV and AIDS
Drug name
Dosage/route
Usual indications
Non-nucleoside reverse transcriptase inhibitors
efavirenz (Stocrin)
Adult: 600 mg/day PO
Paediatric: dose determined by age and weight
Treatment of adults and children with HIV
in combination with other antiretroviral
agents
etravirine (Intelence)
Adult: 200 mg/day PO
Treatment of adults with HIV where viral
replication is evident and resistant to
other antiretrovirals
nevirapine (Viramune)
Adult: 200 mg/day PO for 14 days, then
200 mg PO b.d.
Paediatric: 4 mg/kg PO for 14 days, then
4–7 mg/kg PO b.d.
Treatment of adults or children with HIV
in combination with other antiretroviral
agents
rilpivirine (Edurant)
Adult: 25 mg/day PO
Treatment of adults with HIV
Nucleoside reverse transcriptase inhibitors
abacavir (Ziagen)
Adult: 300 mg PO b.d.
Paediatric: 8 mg/kg PO b.d.
Combination therapy for the treatment of
adults and children with HIV
didanosine (Videx)
Adult: 250–400 mg/day PO or 125–200 mg
PO b.d.
Paediatric >6 months: 100 to 300 mg/m
2
/day
Treatment of advanced infections in
adults and children with HIV as part of
combination therapy
emtricitabine (Emtriva)
Adult: 200 mg/day PO or 240 mg oral solution/
day
Part of combination therapy for treatment
of HIV-1 infection
lamivudine (Combivir, 3TC,
Zeffix)
Adult: 100 mg/day PO
Paediatric 2–11 years: 3 mg/kg/day PO
With other antiretroviral agents for the
treatment of adults and children with HIV;
as an oral solution for the treatment of
chronic hepatitis B
stavudine (Zerit)
Adults >60 kg: 40 mg PO q 12 hours
Adults <60 kg: 30 mg PO q 12 hours
Treatment of adults with HIV in
combination with other antiretroviral
agents
tenofovir (Viread)
Adult: 300 mg/day PO
Treatment of adults with HIV infection
in combination with other antiretroviral
drugs
zidovudine [AZT]
(Retrovir)
500 mg PO b.d.
Treatment of symptomatic HIV in adults as
part of combination therapy
Protease inhibitors
atazanavir (Reyataz)
Adult: 400 mg/day PO
Treatment of adults with HIV as part of
combination therapy
darunavir (Prezista)
Adult: 800 mg/day PO
Paediatric: No more than 600 mg/day PO with
ritonavir 100 mg PO b.d.
Treatment of adults and children with HIV
as part of combination therapy
fosamprenavir (Telzir)
Adult: 1,400 mg/day PO with 100 mg/day
ritonavir PO or 700 mg PO b.d. with ritonavir
100 mg PO b.d.
Part of combination therapy for the
treatment of HIV in adults
indinavir (Crixivan)
Adult: 800 mg PO q 8 hours
Treatment of adults with HIV as part of
combination therapy
lopinavir (Kaletra)
Adult and paediatric >35 kg: 400 mg PO b.d.
Treatment of adults and children with HIV
in combination with other antiretroviral
agents
ritonavir (Norvir)
Adult and paediatric (>2 years): 600 mg PO
b.d.
Part of combination therapy for the
treatment of adults and children with HIV
saquinavir (Invirase)
1000 mg PO b.d. with ritonavir 100 mg PO b.d.
Treatment of adults with HIV as part of
combination therapy
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