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18
Chapter 1
C
Striatum:
reward e ect on cognitive exibility
reward anticipation e ect
in ventral striatum
reward e ect on switching
(caudate nucleus)
-2
0
2
4
1
2
9R carriers
10R homozygotes
0
R = 0.49,
p = 0.03
D
target
( task switch
/ repeat)
10 cent
arrow
le
correct!
10 cent
response
deadline
reward cue
(10 / 1 cent)
task cue
(arrow / word)
feedback
-0.3
-0.2
-0.1
0
0.1
0.2
0.3
0.4
0.5
0.6
9R+ 10R/10R
reward e ect on switching
(error rates)
DAT1:
reward e ect on cognitive exibility
A
B
Rewarded task-switching paradigm
0
0.1
0.2
0.3
- 0.8
- 0.4
0.0
0.4
0.8
pre-synaptic dopamine cell integrity
(posterior putamen)
PD:
reward e ect on cognitive exibility
reward e ect on switching
(transformed error rate)
0.2
0
0.4 0.6 0.8
Posterior putamen
Anterior putamen
Caudate nucleus (Cau)
*
PD:
relative reductionof
pre-synaptic dopamine cell integrity
Nacc
AP Cau PP
N. Accumbens (Nacc)
E
F
R = 0.71,
p < 0.001