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Table S3.2c
Mean response times and error rates on reward and switching for the
subgroup of 10R homozygotes who received sulpiride (pre)-treatment (n = 14)
High reward
Low reward
Repeat
Switch
Repeat
Switch
Placebo
Errors (%)
(s.e.m.)
*, 1
9.66
(1.58)
15.68
(1.74)
9.59
(1.82)
17.41
(2.37)
RT (ms)
(s.e.m.)
+
319.14
(10.17)
320.42
(11.24)
323.25
(10.4)
327.7
(12.03)
Bromocriptine
Errors (%)
(s.e.m.)
*
12.09
(2.11)
13.32
(1.63)
13.39
(2.16)
16.06
(2.32)
RT (ms)
(s.e.m.)
+, 2
305.36
(8.39)
310.98
(9.29)
316.62
(10.32)
317.95
(10.58)
Sulpiride
Errors (%)
(s.e.m.)
3
9.29
(1.76)
13.14
(1.87)
13.37
(2.53)
18.73
(2.64)
RT (ms)
(s.e.m.)
323.67
(12.73)
329.18
(14.88)
326.08
(12.47)
335.54
(15)
Sulpiride - bromocriptine
Errors (%)
(s.e.m.)
4
13.69
(2.61)
17.21
(2.82)
15.39
(2.91)
22.19
(3.04)
RT (ms)
(s.e.m.)
310.61
(11.39)
312.35
(10.47)
316.71
(11.98)
315.77
(12.04)
s.e.m. = standard error of the mean
Significant effects:
* Main effect of switching: F(1,13) = 22.1, p < .001], drug * switching: F(1,13) = 5.6, p < .04
+ Main effect of reward F(1,13) = 7.6, p < .02;
1 main effect of switching F(1,13) = 24.4, p < .001;
2 Main effect of reward F(1,13) = 7.8, p < .02;
3 main effect of switching: F(1,13) = 5.1, p < .05; main effect of reward: F(1,13) = 19.7, p < .001;
4 main effect switching F(1,13) = 9.6, p < .009
67
Dopamine D2 receptors and cognitive flexibility