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Background

R-Chemotherapy plus mediastinal IFRT

is considered the standard treatment for

PMBCL (3-yrs PFS: 80-85%)

Does mediastinal IFRT still improve the outcome in PMBCL patients treated with R-

CHOP/R-CHOP like chemotherapy?

Is a negative PET-CT scan a reliable indicator of cure following chemotherapy

alone, making unnecessary consolidation RT?