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On treatment, ongoing response

Off treatment without progression

Progressive disease, following response

or stable disease

–100

–50

0

50

100

Percent Change From Baseline

in Target Lesions/Tumor Burden

0 6 12 18 24 30 36 42 48 54 60 66 72 78 84 90 96 102 108 114

First occurrence of new lesion

Nivolumab in r&r HL

Durability of reponse