1414 / 1835
Hypothesis
•
HDT/ASCT may be overtreating a
subset of patients who have
excellent outcomes in relapsed HL
•
Radiation therapy alone can induce
durable remissions, particularly in
patients with early stage disease at
relapse
•
Radiation therapy induces a diverse
repertoire of anti-tumor T cells, but
progression is associated with
upregulation of the immune
checkpoint PD-L1
Josting et al,
J Clin Oncol
2005
PD-L1 IHC
Responder
Non-responder