1486 / 1835
Conclusions: Authors
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After a negative interim FDG-PET scan it is safe to omit bleomycin from
subsequent cycles without consolidation with radiotherapy.
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Omission of bleomycin reduces toxicity
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Escalated therapy for interim FDG-PET positive patients gives good
subsequent response rates and promising PFS results (70 % 3 yr PFS for PET
3 negative)
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Conclusions-mine
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This is a large study with good results that likely practice changing
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Safely omitting bleo if concern
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Guidance/strategy for interim PET positive
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? True PFS of interim PET2+ with 4 more ABVD – many received RT
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No guidelines for RT use