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PCNSL Baseline Evaluation
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Pathologic Evaluation
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Centralized confirmation of pathology with immunopathology when possible
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Clinical Evaluation
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Complete medical, neurological, cognitive examination
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Determination of prognostic factors (age, PS)
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Laboratory Evaluation
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HIV, lactate dehyrogenase, creatinine clearance
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Extent of Disease Evaluation
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Brain- Contrast-enhanced cranial MRI
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CSF- Cytology, flow cytometry, IgH PCR
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Eye- Slit lamp evaluation
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Body- CT of chest/abdomen/pelvis; BM biopsy + aspirate. Consider testicular US in older men