1533 / 1835
PCNSL
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Neurotoxicity
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Risk Factors
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Age > 60, MTX followed by full-dose whole brain RT
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Clinical Features
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Imaging changes evident in most patients by 6 months after radiation
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Clinical changes began at a median of 1 month in one study
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Four domains most sensitive to disease and treatment
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Attention
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Executive Functions
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Memory
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Psychomotor Speed
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Occurs in many patients > 60 treated with MTX-WBRT (full dose)