1688 / 1835
Preliminary results suggest a
positive effect of these drugs on PFS
Median follow-up: 21 months (5-60)
110 (50%) pts remain failure-free
A: 24 (32%)
B: 37 (54%)
C: 49 (65%)
Failure: primary site involvement,
usually the brain, in 97% of cases
Extra-CNS relapse in two pts.
No differences in salvage efficacy
(65% of failed pts).
A vs. B= 0.01
A vs. C= 0.00005
B vs. C= 0.13