1719 / 1835
Local diagnosis of PMBL
Registration
Baseline PET/CT
R-CHEMO
RCHOP 14-21; R-V/MACOP-B
DA R-EPOCH; R-ACVBP;R
mega-CHOP
Restaging PET/CT
Central Panel Review
PET/CT positive
PET/CT negative
Randomise (n=376)
Observation
Mediastinal IFRT
Investigator choice
of therapy
(follow-up for PFS
and OS)