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HL treatment changes since 1965
MOPP: Mechlorethamine, vincristine, procarbazine, prednison
ABVD: Doxorubicin, bleomycin, vinblastine, dacarbazine
ABV:
Doxorubicin, bleomycin, vinblastine
BEACOPP: Bleomycin, etoposide, doxorubicin, cyclophosphamide,
vincristine, procarbazine, prednison
Chemotherapy
Radiotherapy
Trend: ↓ dose alkylating
Trend: ↓ RT target volumes, ↓ RT dose
<1980
MOPP(like) & single agents
<1980
Classical fields
1980-1995 MOPP/ABVD; MOPPABV
1980-1995
Classical fields; IFRT
>1995
ABVD; MOPP-ABV; EBVP; BEACOPP >1995
IFRT
>2012
Brentuximab-vedotin containing regimens >2006
INRT; ISRT
Hodgson, ASH educational 2011