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Class I PI3K
isoform
1
Expression
Ubiquitous
Ubiquitous
Leukocytes
Leukocytes
EC
50
nM
>20,000
1900
3000
8
Idelalisib is highly selective for PI3Kδ isoform
Promising activity in relapsed / refractory (R/R) indolent non-Hodgkin
lymphoma (iNHL) in a Phase I study
2
1. Lannutti BJ, et al. Blood 2011;117:591-4;
2. Flinn IW, et al. Blood 2014;123:3406-13
;