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…but how can we improve the outcomes for those

with less favourable prognosis?

Ziepert at al. J Clin Oncol 28:2373-2380.

Age adjusted IPI

Stage

LDH

Performance status

IPI

Age greater than 60 years

Stage III or IV disease

Elevated serum LDH

ECOG > 2

More than 1 extranodal site