571 / 1835
MYC
translocations
Savage K J et al. Blood 2009;114:3533-3537
►
Present in 5-10%
►
Typically t(8:14)(q24;q32) but non-Ig
locus
►
5 year PFS 31% vs 66% (P=0.006)
►
Higher risk of CNS recurrence
►
No particular baseline clinical feature
►
Complex karyotype
►
MYC
FISH for all patients?
►
Median presentation in 7th
decade…limits options for therapy
►
Impact of non-
IGH
partners