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HD12 trial design for advanced stages
De-escalation of RT possible?
Arm D
4 + 4
Arm B
8 x B esc
Arm C
4 + 4
Arm A
8 x B esc
Randomisation
30 Gy
(initial bulk, residual)
„no RT“
30 Gy
(initial bulk, residual)
„no RT“
Central diagnostic panel