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RT can induce immunogenic tumour cell death (ICD)

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Understanding more about effect of RT dose and fractionation on DAMP

release and ICD will be important in making progress

RT a potentially important component to improve systemic anti-tumour

immunity

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Overcoming extrinsic tumor micro-environmental immunosuppressive factors

critical to exploiting systemic anti-tumour immune responses to RT

The efficacy of RT can be greatly enhanced in combination with

immunoregulatory agents and holds great promise to improve outcome

for a range of cancers

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Well designed clinical trials required with high quality translational science

including immunological biomarkers of response