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SMPR Key Points
Applicability
• Must quantitate
Definition
For this SMPR, active
multiple forms of
vitamin B
12
individually in a
variety of dosage
forms.
vitamin B
12
is defined
as the following:
• Methylcobalamin
• Cyanocobalamin
Adenosylcobalamin
• Must distinguish
active vitamin B
12
corrinoids from
inactive forms.
•
• Hydroxocobalamin
Matrices for Vitamin B
12
Supplements
• Tablets
• Capsules
• Liquids
• Powders
• Extracts
• Microbial products
• Gummies
• Softgels
• Sublingual forms
• Chewables