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Challenges in Optimal Endocrine therapy
• Predictive markers beyond ER,PR
• Understanding pathways of resistance
• Optimizing host environment (BMI?)
• Monitoring long term benefit & toxicity
• Compliance of patient
• Dissemination of endocrine prevention strategies for high
risk women
• New treatment combinations targeting both ER and
growth factor receptor signaling to block the crosstalk
between these pathways and eliminate escape routes
19-9-2017