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PARPs: poly(ADP-ribose) polymerases
• Superfamily of 16 members.
• 6 have poly(ADP-ribosyl)ating
activity
• PARP-1 accounts for more
than 90% of this activity.
• Share a common catalytic site
• Inhibitors are often analogues
of its substrate NAD> will
inhibit many PARPs
Schreiber et al. Nature Reviews Molecular Cell Biology
7
, 517–528 (July 2006)