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Take home message
Classical prognostic factors of breast cancer are the patient's age and
performance status, in addition to tumor related factors such as tumor size,
lymph node status, hormone receptor status, HER2 status, tumor grade and
proliferation index
Adjuvant! and Predict are validated for prediction prognosis of the individual
patient and predictive for absolute risk reduction because of adjuvant
treatment
If there is doubt about the indication of adjuvant chemotherapy based on the
classical prognostic factors, a gene expression profile may be used in
addition to the classic prognostic factors (eg. in patients> 35 years with pT1-
2N0 ER positive and HER2 negative invasive ductal breast cancer)
Gene expression profiles have prognostic significance in addition to the known
classical clinical and pathological factors. They can not replace the classical
clinical and pathological factors.
19-9-2017