1309 / 1816
The increase in relative risk of LRR in the meta-analysis is
mainly due to 3 trials without surgery in case of cCR
Rel. risk of locoregional relapse in the 3 studies was 1.53 (1.17-2.00
)
Cochrane review
No increase in local-regional recurrence rates if surgery is
part of treatment (HR=1.112; 0.92 – 1.37)*
*vd Hage, Cochrane 2007