1329 / 1816
Conclusion neoadjuvant chemotherapy
Safe application of preoperative
chemotherapy in the treatment of women with
early stage breast cancer in order to down-
stage surgical requirement, to evaluatie
chemosensitivity and to facilitate translational
research
Safe application of NAC in treatment of women with early stage breast
cancer in order to down-stage surgical requirement, to evaluate
chemosensitivity and to facilitate translational research*
• Survival and ipsilateral breast recurrence is comparable after neoadjuvant and
adjuvant chemotherapy, NAC = safe therapy
• Prognostic information
• Assessment of in vivo response to therapy with NAC
• Excellent tool for translational research
• Accelerated approval new drugs
Future
• Allows better individualization of therapy according to mid-course treatment effect
•
Using early information treatment effect can serve to design better treatment
• Spare patients from further regional treatment who are downstaged from a positive to
a negative LN status
*Vd Hage, Cochrane 2007