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Take Home Messages
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Indication for locoregional RT depends on both pre-treatment
characteristics and ypTNM status
•
For patients with cT4 disease or cT3N+ disease and/or cN2/3: locoregional
RT is currently indicated independent of response.
•
For patients with cT1-2(3)N0-1 disease, lots of studies are ongoing:
•
Re-staging: SN + clipped node seems most promising:
Note: pCR
does not always mean that LR treatment is not required anymore !!
•
Hardly any data available on longterm follow-up of reduced
treatment !
•
Data of prospective cohort studies applying reduced treatment are
maturing
•
RCTs are recruiting..
It will take at least 5 - 10 years before we have sufficient long term follow-
up before we have real evidence for reduced treatment