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N = 1135

Invasive; < 20 mm; N0; G1 or good prognosis subtype

2x2 clinical trial of factorial design:

+/- radiotherapy &

+/- tamoxifen

Trial entry was allowed to either comparison or both.

Blamey RW, et al. Eur J Cancer. 2013;49:2294-302.

Less local treatment: The role of RT in BCT