497 / 1816
ECOG E5194 (PARENT STUDY)
Prospective multicenter study 1997-2000 (n = 670)
cohort 1: low/intermediate grading, extent < 2.5 cm
cohort 2: high grading, extent < 1 cm
Treatment
- Surgical excision
- free margins at least 3 mm
- no RT
- Tamoxifen optional
Solin et al. JNCI 2013
2011; Abstract S4-6.