518 / 1816
Summary: risk on LR and on dying from DCIS
All studies show that:
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RT after lumpectomy reduces local recurrences
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About 50% of LR are invasive
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Risk of dying of breast cancer after DCIS is very low (2-3%)
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IF an invasive recurrence develops: risk of dying from breast cancer
increases enormously (18 fold acc. to SEER data Narrod et al)
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But: preventing invasive LR by RT does not influence breast cancer
specific survival…?!
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Suggestion that RT indeed does improve survival in subgroups
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We need more knowledge on biology, apart from Grade
03/01/13