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Cranial germinoma
Evolution of germinoma therapy
chemotherapy
radiotherapy
radiotherapy
cranio-spinal axis 36 Gy + boost to tumour site 14Gy
(
total tumour dose 50Gy)
Carboplatin
Etoposide
Bleomycin
tumour site alone
(
total tumour dose 40Gy)
cranio-spinal axis 24Gy + boost to tumour site 16Gy
(
total tumour dose 40Gy)
dose reduction
volume reduction
whole brain or whole ventricular RT 24Gy + boost to tumour site 16Gy
(
total tumour dose 40Gy)
chemotherapy
& volume reduction
International multicentre study
(consortium)
Balmaceda
et al 1996, J Clin Oncol, 14: 2908-2915