1296-1297 / 2437
IELSG-32 trial
PCNSL [≤ 65 years, PS 0-3] or [65-70 years, PS ≤2]
®
®
WBRT 36 Gy
±
Boost 9 Gy
BCNU 400 mg/m
2
D1
Thiotepa 5 mg/kg x 2/d; D2-3
+ APBSCT
4x MTX 3.5 g/m
2
D1
AraC 2 g/m
2
x 2/d, D2-3
x 3 weeks
4x
Rituximab 375 mg/m
2
D-5/0
MTX 3.5 g/m
2
D1
AraC 2 g/m
2
x 2/d, D2-3
x 3 weeks
4x
Rituximab 375 mg/m
2
D-5/0
MTX 3.5 g/m
2
D1
AraC 2 g/m
2
x 2/d, D2-3
Thiotepa 30 mg/m
2
D4
x 3 weeks
Response assessment
CR – PR - SD
PD – Tox
SC Harvest
WBRT 40 Gy
±
Boost 9 Gy